ABSTRACT
The distribution of HLA class-I (A, B and C), and class II (DR and DQ) antigens was studied in 50 randomly selected Kashmiri Muslim patients with established rheumatic heart disease and compared with that of 50 controls of similar ethnicity. A significant increase in the frequency of HLA-DR4 (P < 0.005, RR 3.27) and a significant decrease in the frequency of HLA-B5 (P < 0.001, RR 0.19) were found in the patient group. Though HLA-DQ3 showed a significant increase (P < 0.005, RR 2.52) and HLA-DR7 a significant decrease (P < 0.05, RR 0.42) in the patient group, the corrected P value was not significant. The findings suggest that susceptibility to RHD in the studied population is HLA-related, with HLA-DR4 influencing its occurrence and HLA-B5 conferring protection against the same.
Subject(s)
Adolescent , Adult , Case-Control Studies , Female , HLA Antigens/blood , Humans , India , Islam , Male , Middle Aged , Rheumatic Heart Disease/immunologySubject(s)
Adolescent , Antigens, Bacterial/analysis , Bacterial Outer Membrane Proteins , Bacterial Proteins/analysis , Carrier Proteins , Child , Child, Preschool , Deoxyribonucleases/analysis , Female , Humans , Male , Polysaccharides, Bacterial/analysis , Rheumatic Fever/immunology , Rheumatic Heart Disease/immunology , Streptococcus/immunology , Streptolysins/analysisABSTRACT
La fiebre reumática es una enfermedad muy frecuente en nuestro medio, sobre todo en niños de edad escolar y adolescentes. Una de sus manifestaciones es la cardiopatía reumática, causante de diversos grados de invalidez y aun de muerte. En su etiopatogenia los mecanismos inmunológicos de lesión tisular en corazón, sistema vascular y otras, adquieren relieves de significación, como en el caso de las enfermedades "autoinmunes" producidas por el estreptococo beta hemolítico del grupo A, en las que un cierto número de pacientes presentan cuadros de fiebre reumática o de glomerulonefritis aguda posestreptocócica, como secuelas de la infección del aparato respiratorio o de la piel por dicho agente microbiano